UltraPlasma™ Multi-Platform Plasma Systems for Warts (aka Verruca Vulgaris):
A Comprehensive Treatment Spectrum

Introduction

Warts are benign proliferations of the skin and mucosa caused by human papillomavirus (HPV). Warts are non-cancerous viral growths usually occurring on the hands and feet but which can also affect other locations, such as the genitals or face. One or many warts may appear. They are distinguished from cancerous tumors as they are caused by a viral infection, such as a human papillomavirus, rather than a cancer growth.

Factors that increase the risk include the use of public showers and pools, working with meat, eczema, and a weak immune system. The virus is believed to infect the host through the entrance of a skin wound. A number of types exist, including plantar warts, filiform warts, and genital warts. Genital warts are often sexually transmitted.

Without treatment, most types of warts resolve in months to years. Treatments do speed resolution with UltraPlasma™. In those who are otherwise healthy, they do not typically result in significant problems. Treatment of genital warts differs from that of other types. Infection of a virus, such as HIV, can cause warts. This is prevented through careful handling of needles or sharp objects that could infect the individual through physical trauma of the skin, plus the practice of safe sex using barrier methods such as condoms. Viruses that are not sexually transmitted, or are not transmitted in the case of a wart, can be prevented through a number of behaviors, such as wearing shoes outdoors and avoiding unsanitized areas without proper shoes or clothing, such as public restrooms or locker rooms.

Warts are very common, with most people being infected at some point in their lives. The estimated current rate of non-genital warts among the general population is 1–13%. They are more common among young people.

Their treatment requires both viral clearance and local tissue regeneration. UltraPlasma™, an advanced system that integrates arc, argon, and helium plasma technologies with a custom software and hardware-controlled output spectrum, introduces a novel multi-gas plasma therapeutic strategy tailored for effective wart removal, immunological modulation, and dermal regeneration.

Types of Warts (Verruca Vulgaris)

A range of types of wart have been identified, varying in shape and site affected, as well as the type of human papillomavirus involved. These include:

• Common wart (verruca vulgaris), a raised wart with a roughened surface, most common on hands, but can grow anywhere on the body. Sometimes known as a Palmer wart or Junior wart.

• Flat wart (verruca plana), a small, smooth flattened wart, flesh-coloured, which can occur in large numbers; most common on the face, neck, hands, wrists, and knees.

• Filiform or digitate wart, a thread- or finger-like wart, most common on the face, especially near the eyelids and lips.

• Genital wart (venereal wart, condyloma acuminatum, verruca acuminata), a wart that occurs on the genitalia.

• Periungual wart, a cauliflower-like cluster of warts that occurs around the nails.

• Plantar wart (verruca, verruca plantaris), a hard, sometimes painful lump, often with multiple black specks in the center; usually only found on pressure points on the soles of the feet.

• Mosaic wart, a group of tightly clustered plantar-type warts, commonly on the hands or soles of the feet.

1. UltraPlasma™ System Overview

1.1 Plasma Sources

• UltraPlasma™ Arc Plasma Mode (White-Blue): High-energy microdischarge used for ablation and viral particle disruption.

• UltraPlasma™ Argon Plasma Mode (Blue-Purple): Stable and thermally modulated gas plasma ideal for skin surface sterilization and non-invasive tissue stimulation.

• UltraPlasma™ Helium Plasma Mode (Violet): Cold plasma with deep dermal reach, promoting wound healing and biofilm disruption.

1.2 Software-Controlled Output

The embedded software allows:

• Custom waveform and frequency modulation

• Real-time impedance matching with skin tissues

• Adjustable gas mixture ratios (O₂, O₃, N₂, Ar, He)

• Output tuning for wart type (common, plantar, flat, filiform, periungual)

2. Pathophysiology of Warts and Plasma Strategy

3. Plasma-Tissue Interactions

3.1 Epidermis

• Ultra Plasma™ disrupts keratinocyte integrity and HPV replication centers.

• Ultra Plasma™ arc plasma exfoliates hyperkeratotic tissue.

• Ultra Plasma™ argon plasma oxidizes surface viral proteins.

3.2 Dermis

• Ultra Plasma™ helium plasma modulates fibroblast activation.

• NO (nitric oxide) from plasma supports angiogenesis.

• Ultra Plasma™ -derived ROS/RNS act on viral RNA/DNA.

3.3 Hypodermis

• Enhanced microcirculation via vasodilation (NO effect).

• Immune signaling boosted through plasma-generated cytokine mimetics.

4. Gas Species and Biomedical Effects

5. Clinical Benefits of UltraPlasma™ for Warts

• Non-contact ablation minimizes scarring

• Selective depth penetration reduces recurrence

• Immunomodulatory effects prevent reinfection

• Painless treatment, no anesthesia required

• Minimal downtime and safe for all age groups

Figure 1: Multi-Platform Plasma Emission Spectrum of UltraPlasma™

Figure 3: Wart Progression – Before & After UltraPlasma™ Treatment

Figure 2: Cross-Sectional View of Skin with Wart & UltraPlasma™ Penetration

⌘Conclusion⌘

The UltraPlasma™ multi-platform system represents a paradigm shift in dermatological plasma medicine, especially for wart treatment. Its integration of arc, argon, and helium plasmas with precision-controlled reactive gas delivery enables effective viral ablation, immune stimulation, and tissue regeneration in one system. From superficial flat warts to deep plantar types, this technology delivers patient-specific, safe, and recurrence-resistant therapy.

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